Comic #3287: 2014-05-18

Description

Here's the transcription of the comic:

Panel 1: Doctor: "You'll be all right, Mister Pigliucci, but I'm afraid…" Doctor (thinking): "Your anus will never be the same."

Panel 2: Patient: "What?! But it was a routine colonoscopy!" Patient (shocked): "My god, man! What went wrong?!"

Panel 3: Doctor: "Oh, sorry, I meant that in the philosophical sense. You know, Heraclitus once said, 'You can never step in the same river twice.' Well, the molecular makeup of your anus changes, just like a river!"

Panel 4: Patient: "You use this joke on all your patients, don't you?" Doctor: "Technically, it's never exactly the same joke."